Optimization of inhibition efficiencies process of polyvinylpyrrolidone using response surface methodology


  • A. Benchadli University Abou Beker Belkaid Tlemcen
  • T. Mellal University Abou Beker Belkaid Tlemcen
  • T. Attar University Abou Beker Belkaid Tlemcen
  • Boumédiène Dali Youcef Laboratoire de Recherche sur les Macromolécules, Université Abou Bekr Belkaïd, 13000 Tlemcen http://orcid.org/0000-0002-2618-080X
  • E. Choukchou-Braham University Abou Beker Belkaid Tlemcen




Inhibition efficiencies, Polyvinylpyrrolidone, acid perchloric, central composite face-centered design (CCFCD), response surface methodology


Inhibition efficiencies (IE) process in polyvinylpyrrolidone (PVP) which is influenced by independent factors, concentration and size of PVP, temperature, time of immersion, and perchloric acid concentration was investigated in this paper. The relationship between factors and their responses is established by the concept of response surface methodology (RSM) explicitly through regression statistical analysis and probabilistic analysis is used in this work. The concept is a combination of mathematical and statistical techniques allowing the modeling and problems analysis by experimental design. In this study, the results based on statistical analysis showed that the quadratic models for the inhibition efficiencies (IE) were significant at the value of probability P < 0.0001 and the coefficient of multiple regressions R2=0.9997, for further validation of the model, R2Adj=0.9993 indicated a good model. The observed experimental values were in good agreement with predicted ones and the model was
highly significant with Q2= 0.9884. The optimal conditions of inhibition efficiencies (IE) obtained are 104.301% for a concentration of 3.55×10−3 mol/L, temperature of 20.15°C, immersion time of 2h, size of PVP 58000 g/mol, and acid concentration of 0.5 mol/L.

Author Biography

Boumédiène Dali Youcef, Laboratoire de Recherche sur les Macromolécules, Université Abou Bekr Belkaïd, 13000 Tlemcen

Département de physiuqe



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How to Cite

A. Benchadli, T. Mellal, T. Attar, B. Dali Youcef, and E. Choukchou-Braham, “Optimization of inhibition efficiencies process of polyvinylpyrrolidone using response surface methodology”, Rev. Mex. Fís., vol. 68, no. 4 Jul-Aug, pp. 041003 1–11, Jun. 2022.