Dosimetría tridimensional por Monte Carlo del tratamiento tópico con 188Re de carcinoma de células escamosas y células básales

Dosimetría del tratamiento tópico de cancer con Re-188


  • W. Rodríguez-Herklotz Universidad Autónoma del Estado de México
  • Eugenio Torres-García Universidad Autónoma del Estado de México
  • G. Ferro-Flores Instituto Nacional de Investigaciones Nucleares
  • K. Isaac-Olivé Universidad Autónoma del Estado de México
  • L. Aranda-Lara Universidad Autónoma del Estado de México



Dosimetry, Monte Carlo Simulation, brachytherapy, Renium-188


Basal and squamous cell carcinoma is currently treated mainly by surgery. In search of non-invasive treatments, the topical treatment with 188Re was developed, which has shown satisfactory therapeutic results. However, there are currently only two-dimensional descriptions of the absorbed dose distribution in the target region, which limits the information regarding to the absorbed dose (D) imparted to surrounding healthy tissue. Methodology. The simulation scenario was a cream containing a uniformly distributed 188Re, a mylar plastic sheet, and a voxel type phantom representing the skin with a volume of ​​2X2X0.1 cm3 and a voxel size of 100 µm per side. The isodose surfaces, as well as the curves in the sagittal and transverse sections, were analyzed to describe the dose distribution. Results and Conclusion. The Homogeneity Index reveals how homogeneity decreases as depth increases. Tables are reported with the irradiation time necessary to deliver a 50 Gy radiation dose in a 250-750 µm depth range. With the therapeutic configuration described in this work, which is the one used in clinical practice, it was found that it is possible to give a treatment to a depth of 250-650 µm without exceeding the limit of absorbed dose recommended for the epidermis, which is exceeded if the prescribed radiation dose is reached at a depth of 750 µm.


J. D. Lee, Radionuclide therapy of skin cancers and Bowen’s disease using a specially designed skin patch, J. Nucl. Med. 38 (1997) 697.

Y. L. Chung, J. D. Lee, D. Bang, J. B. Lee, K. B. Park, M. G. Lee, Treatment of bowen’s disease with a specially designed radioactive skin patch, Eur. J. Nucl. Med. 27 (2000) 842.

A. F. Sedda, G. Rossi, C. Cipriani, A. M. Carrozzo, P. Donati, Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma, Clin. Exp. Dermatol. 33 (2008) 745.

J. M. Jeong, Y. J. Lee, E. H. Kim, Y. S. Chang, Y. J. Kim, M. Son, et. al., Preparation of 188Re-labeled paper for treating skin cancer, Appl. Radiat. Isot. 58 (2003) 551.

A. Pashazadeh, M. Robatjazi, N. J. Castro, M. Friebe, A multiwell applicator for conformal brachytherapy of superficial skin tumors: A simulation study, Ski. Res. Technol. 26 (2020) 537.

C Cipriani, Personalized High-Dose-Rate Brachytherapy with Non-Sealed Rhenium-188 in Non-Melanoma Skin Cancer, Int. J. Nucl. Med. Res. Special (2017) 114.

C. Cipriani et al., Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study, J. Dermatolog. Treat. 1 2020 1.

C. J. Werner, et. al., MCNP user’s manual - Code Version 6.2, Los Alamos Nuclear Laboratory, report La-Ur-17-29981, (2017).

B. Emami, Tolerance of Normal Tissue to Irradiation, Int. J. Radiat. Oncol. Biol. Phys. 21 (1991) 109.

A. Ginot, J. Doyen, J. M. Hannoun Lévi JM, A. Courdi, Dose de tolerance des tissus sains: la peau et les phanéres, Cancer/Radiotherapie. 14 (2010) 379.

J. O. Archambeau, R. Pezner, T. Wasserman, Pathophysiology of irradiated skin and breast, Int. J. Radiat. Oncol. Biol. Phys. 31 (1995) 1171.

S. Chan, A. S. Dhadda, R. Swindell, Single Fraction Radiotherapy for Small Superficial Carcinoma of the Skin, Clin. Oncol. 19 (2007) 256.

A. J. McPartlin, N. J. Slevin, A. J. Sykes, A. Rembielak , Radiotherapy treatment of non-melanoma skin cancer: A survey of current UK practice and commentary, Br. J. Radiol. 87 (2014) 20140501.




How to Cite

W. Rodríguez-Herklotz, E. Torres-García, G. Ferro-Flores, K. Isaac-Olivé, and L. Aranda-Lara, “Dosimetría tridimensional por Monte Carlo del tratamiento tópico con 188Re de carcinoma de células escamosas y células básales: Dosimetría del tratamiento tópico de cancer con Re-188”, Rev. Mex. Fís., vol. 68, no. 4 Jul-Aug, pp. 041101 1–, Jun. 2022.