Effect of transverse magnetic field on dose distributions of yttrium 90 skin patch source
Keywords:Beta radiation, transverse magnetic field, superficial brachytherapy, skin patch source, GAMOS
The total dose absorbed on the tumor cell from the skin patch sources used in clinical superficial brachytherapy should be limited within the target tumor volume in order to minimize the potential side effects. Average range of the beta particles within tissue may exceed the thickness of a superficial skin tumor beyond the target tumor volume, causing side effects by damaging the deeper located healthy tissue and the bone underneath the tumor. It is desired to minimize the possible side effects by selecting a short-range radionuclide. Administering the treatment under an external magnetic field is another option for reducing side effects. To achieve this, in this study, the percentage deep dose (PDD) and transverse dose profile (TDP) distributions of the skin patch source labeled with Yttrium 90 (90Y) using the GEANT4-based GAMOS Monte Carlo code were examined before and after applying magnetic field, and it was evaluated whether it was possible to limit the dose within a certain volume or not.
Simulation results showed that, along with the application of a transverse magnetic field, the dose values increased by 7.2% and 3.1% respectively at 0.25 mm and 1.0 mm depths whereas it decreased by 9.4%, 25.0%, 41.8% and 57.6%, at 2.0 mm, 3.0 mm, 4.0 mm and 5.0 mm depths respectively on the central axis from the surface of the tissue phantom with respect to the 0 T values of the field. In case of a superficial skin tumor with a thickness of 3.0 mm from the skin surface, the amount of dose accumulated in the tumor volume for 0 T value of the transverse magnetic field was 89% of the total dose, while it increased to 98% at the intensity of 1.5 T, and the dose received by the healthy tissue under the tumor decreased by 10.1%.
Anjali, V. R. "Basics of Brachytherapy and Common Radio Nucleotides." Practical Radiation Oncology. (Springer, Singapore, 2020), pp. 103-108.
Jeong, Jae Min, et al. Preparation of 188Re-labeled paper for treating skin cancer. Appl Radiat Isot. 58 (2003) 551. https://doi.org/10.1016/S0969-8043(03)00063-0
Lee, Jong Doo, et al. Radionuclide therapy of skin cancers and Bowen's disease using a specially designed skin patch. J Nucl Med. 38 (1997) 697.
Salgueiro, M. J., et al. Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases. Appl Radiat Isot. 66 (2008) 303. https://doi.org/10.1016/j.apradiso.2007.09.008
Pashazadeh, Ali, et al. Superficial skin cancer therapy with Y‐90 microspheres: A feasibility study on patch preparation. Skin Res. Technol. 26 (2020) 25. https://doi.org/10.1111/srt.12758
Bostick, W. H. Possible techniques in direct-electron-beam tumor therapy. Physical Review 77 (1950) 564. https://doi.org/10.1103/PhysRev.77.564
E. Nardi, G. Barnea Electron beam therapy with transverse magnetic fields Med Phys, 26 (1999) 967. https://doi.org/10.1118/1.598490
Chen, Yu, et al. Magnetic confinement of electron and photon radiotherapy dose: a Monte Carlo simulation with a nonuniform longitudinal magnetic field.Med Phys 32 (2005) 3810. https://doi.org/10.1118/1.2011091
Reiffel, L., et al. Control of photon beam dose profiles by localized transverse magnetic fields. Physics in Medicine & Biology 45 (2000) 177. https://doi.org/10.1088/0031-9155/45/12/401
Moreno-Barbosa, Fernando, et al. Monte Carlo simulation of the effect of magnetic fields on brachytherapy dose distributions in lung tissue material. Plos one 15 (2020): e0238704. https://doi.org/10.1371/journal.pone.0238704
B. Çavuşoğlu, et al. Experimental and Simulation Analysis of Radiation of the Beta Emitting Sources in a Magnetic Field. Mol Imaging Radionucl Ther. 26 (2017) 53. https://doi.org/10.4274/mirt.30932
S. Sucu, Analysis of Emission of Beta Emitting Radiation Sources Under Experimental Conditions In a Magnetic Field (2010)
Guo, Peng, and Vladimir Gasparian. Charged particles interaction in both a finite volume and a uniform magnetic field. Physical Review D 103 (2021) 094520. https://doi.org/10.1103/PhysRevD.103.094520
Raylman, Raymond R., et al. Magnetically-enhanced radionuclide therapy (MERiT): in vitro evaluation. Int. J. Radiat. Oncol. Biol. Phys 37 (1997) 1201. https://doi.org/10.1016/S0360-3016(96)00616-5
Arce, Pedro, et al. GAMOS: A Geant4-based easy and flexible framework for nuclear medicine applications.IEEE Nuclear Science Symposium Conference Record. (2008). https://doi.org/10.1109/NSSMIC.2008.4775023
Dubois, Pedro Arce, et al. A tool for precise calculation of organ doses in voxelised geometries using GAMOS/Geant4 with a graphical user interface. Polish J. Medical Phys 27 (2021) 31. https://doi.org/10.2478/pjmpe-2021-0005
Amato, Ernesto, et al. Full Monte Carlo internal dosimetry in nuclear medicine by means of GAMOS. J. Phys. Conf. Ser. 1561 (2020) 012002. https://doi.org/10.1088/1742-6596/1561/1/012002
Cross, W. G., et al. Dosimetry of beta rays and low-energy photons for brachytherapy with sealed sources, ICRU Report 72. (2003) 172. https://doi.org/10.1093/jicru/ndh020.
Vynckier, Stefaan, and André Wambersie. Dosimetry of beta sources in radiotherapy. I. The beta point source dose function. Phys. Med. Biol 27 (1982) 1339. https://doi.org/10.1088/0031-9155/27/11/004
Pashazadeh, Ali, et al. Calculation of beta radiation dose of a circular Y-90 skin patch: Analytical and simulation methods Radiat. Phys. Chem 166 (2020) 108491. https://doi.org/10.1016/j.radphyschem.2019.108491
CUI, Zhenguo, et al. The impact of a magnetic field on the dose distribution using the Bebig 60Co HDR sources. Chin. J. Cancer Res. 29 (2020) 193. https://doi.org/10.3760/cma.j.issn.1004-4221.2020.03.008
How to Cite
Copyright (c) 2023 Hakan Epik
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Authors retain copyright and grant the Revista Mexicana de Física right of first publication with the work simultaneously licensed under a CC BY-NC-ND 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.