Numerical study on the fluid-structure interaction and species transport in a piezoresistive microcantilever-based biosensor
DOI:
https://doi.org/10.31349/RevMexFis.71.040601Keywords:
Fluid-structure interaction, Computational Fluid Dynamics, Piezoresistive cantilever, biosensor designAbstract
In this study, we present numerical simulations of the flow-induced deflection of a microcantilever beam and the distribution of a passive analyte inside a microfluidic cell for a piezoresistive biosensor. The numerical implementation was validated using semi-analytical models and previously reported experimental measurements. The primary objective of the study is to understand the impact of the flow on the cantilever's behavior and use this knowledge in the decision-making process for a microfluidic cell design for a piezoresistive biosensor. To accomplish this, the results for three different inlet/outlet configurations allow us to describe the dynamics of the fluid-structure interaction, finding that, for small times, the flow is symmetrical around the microcantilever. As time passes, two vortices surround the microcantilever, resulting in an asymmetric flow distribution. Throughout the entire range of analyzed inlet flow rates, it is evident that the inlet/outlet configuration significantly influences the deflection and stress sustained by the cantilever. Similarly, these configurations affect how the concentration of an analyte sample distributes on the detecting surface. The in-depth understanding of the flow dynamics within the microfluidic cell and its effect on the cantilever, as provided by the simulations, can be used to propose design recommendations aimed at reducing the noise due to the flow, ultimately achieving high sensitivity in these types of devices.
References
A.Moulin, S. O’Shea, and M. Welland, Microcantileverbased biosensors, Ultramicroscopy 82 (2000) 23, https://doi.org/10.1016/S0304-3991(99)00145-X
A. K. Basu, A. Basu, and S. Bhattacharya, Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress, Enzyme and Microbial Technology 139 (2020) 109558, https://doi.org/10.1016/j.enzmictec.2020.109558
A. Mader et al., Discrimination of Escherichia coli Strains using Glycan Cantilever Array Sensors, Nano Letters 12 (2012) 420, https://doi.org/10.1021/nl203736u
V. Dauksaite et al., Antibody-based protein detection using piezoresistive cantilever arrays, Nanotechnology 18 (2007) 125503, https://doi.org/10.1088/0957-4484/18/12/125503
J. Zhang, et al., Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA, Nature Nanotechnology 1 (2006) 214, https://doi.org/10.1038/nnano.2006.134
R. M. R. Pinto, V. Chu, and J. P. Conde, Label-Free Biosensing of DNA in Microfluidics Using Amorphous Silicon Capacitive Micro-Cantilevers, IEEE Sensors Journal 20 (2020) 9018, https://doi.org/10.1109/JSEN.2020.2986497
M. Alvarez, et al., Development of nanomechanical biosensors for detection of the pesticide DDT, Biosensors and Bioelectronics 18 (2003) 649, https://doi.org/10.1016/S0956-5663(03)00035-6
P. Ray, S. Pandey, and V. Ramgopal Rao, Development of graphene nanoplatelet embedded polymer microcantilever for vapour phase explosive detection applications, Journal of Applied Physics 116 (2014), https://doi.org/10.1063/1.4896255
S. Samal et al., Implications of biosensors and nanobiosensors for the eco-friendly detection of public health and agrobased insecticides: A comprehensive review, Heliyon 9 (2023) e15848, https://doi.org/10.1016/j.heliyon.2023.e15848
M. Z. Ansari et al., Improving sensitivity of piezoresistive microcantilever biosensors using stress concentration region designs, Journal of Physics D: Applied Physics 46 (2013) 505501, https://doi.org/10.1088/0022-3727/46/50/505501
I. Sacu and M. Alcı, Design of a basic piezoresistive microcantilever biosensor, IU-Journal of Electrical & Electronics Engineering 13 (2013) 1641
M. Alvarez and L. M. Lechuga, Microcantilever-based platforms as biosensing tools, Analyst 135 (2010) 827, https://doi.org/10.1039/B908503N
J.-Y. Yoon, Introduction to Biosensors: From Electric Circuits to Immunosensors, chap. Wheatstone Bridge, pp. 79-90 (Springer International Publishing Switzerland, 2016), https://doi.org/10.1007/978-3-319-27413-3 5
A. S. Nezhad et al., PDMS Microcantilever-Based Flow Sensor Integration for Lab-on-a-Chip, IEEE Sensors Journal 23 (2013) 601, https://doi.org/10.1109/JSEN.2012.2223667
A. Jana et al., Microcantilever mechanics in flowing viscous fluids, Applied Physics Letters 23 (2007) 114110, https://doi.org/10.1063/1.2713238
C. Lee et al., Design and characterization of MEMSbased flow-rate and flow-direction microsensor, Microfluid. Nanofluidics 23 (2009) 363, https://doi.org/10.1007/s10404-008-0381-6
M.-C. Wu et al., The Effect of Flow Velocity on Microcantilever-Based Biosensors, Journal of Mechanics 23 (2007) 353, https://doi.org/10.1017/S1727719100001404
K. Khanafer, K. Vafai, and M. Gaith, Fluid-structure interaction analysis of flow and heat transfer characteristics around a flexible microcantilever in a fluidic cell, Int. Commun. Heat Mass Transf. 75 (2016) 315, https://doi.org/10.1016/j.icheatmasstransfer.2016.04.025
S. Elmi, Z. Elmi, and M. Bahrami, Numerical simulation for sensitivity and accuracy enhancement of micro cantileverbased biosensor employing truss structure, Microsystem Technologies 25 (2019) 2205, https://doi.org/10.1007/s00542-018-4092-y
A. Saxena et al., Optimization of Newtonian fluid pressure in microcantilever integrated flexible microfluidic channel for healthcare application, Biomed. Phys. Eng. Express 10 (2024) 035015, https://doi.org/10.1088/2057-1976/ad3187
S. Vandana et al., Design and Fluid Structure Interaction Analysis of a Micro-channel as Fluid Sensor, Advanced Engineering Forum 14 (2015) 46, https://doi.org/10.4028/www.scientific.net/AEF.14.46
B. Rodenberg et al., FEniCS-preCICE: Coupling FEniCS to other simulation software, Software X 16 (2021) 100807, https://doi.org/10.1016/j.softx.2021.100807
A. Zanella et al., Towards an open-source framework for FluidStructure Interaction using SU2, MBDyn and preCICE, J. Comput. Appl. Math. 429 (2023) 115211, https://doi.org/10.1016/j.cam.2023.115211
K. Khanafer and K. Vafai, Microcantilevers in biomedical and thermo/fluid applications, Frontiers in Heat and Mass Transfer 1 (2010) 023004, https://doi.org/10.5098/hmt.v1.2.3004
K. Khanafer and K. Vafai, Geometrical and flow configurations for enhanced microcantilever detection within a fluidic cell, Int. J. Heat Mass Transf. 48 (2005) 2886, https://doi.org/10.1016/j.ijheatmasstransfer.2004.11.021
A. Tafuni and I. Sahin, Hydrodynamic loads on vibrating cantilevers under a free Surface in viscous fluids with SPH, In In Proc. ASME 2013 International Mechanical Engineering Congress & Exposition (2013) pp. IMECE2013-63792-1-8
H.-J. Bungartz et al., preCICE - A fully parallel library for multi-physics surface coupling, Computers & Fluids 141 (2016) 250, https://doi.org/10.1016/j.compfluid.2016.04.003
H. G. Weller et al., A tensorial approach to computational continuum mechanics using object-oriented techniques, Computers in Physics 12 (1998) 620, https://doi.org/10.1063/1.168744
OpenFOAM.com, OpenFOAM - The Open Source CFD Toolbox-User’s Guide (2018), https://www.openfoam.com/documentation/user-guide
D. Arndt et al., The deal.II finite element library: Design, features, and insights, Computers & Mathematics with Applications 81 (2021) 407, https://doi.org/10.1016/j.camwa.2020.02.022
D. Arndt et al., The deal.II Library, Version 9.4, Journal of Numerical Mathematics 30 (2022) 231, https://doi.org/10.1515/jnma-2022-0054
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