Low-cost embedded system for optical imaging of intrinsic signals

Authors

  • E. Guevara CONACYT-Universidad Autónoma de San Luis Potosí Terahertz Science and Technology Center (C2T2) and Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, Sierra Leona 550 Lomas 2a secc. San Luis Potosí, SLP, 78210 Mexico. http://orcid.org/0000-0002-2313-2810
  • M. Miranda-Morales Neurobiology of Stress Laboratory, Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, Mexico http://orcid.org/0000-0002-1688-6446
  • K. Hernández-Vidales Terahertz Science and Technology Center (C2T2) and Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, Sierra Leona 550 Lomas 2a secc. San Luis Potosí, SLP, 78210 Mexico.
  • M. Atzori Neurobiology of Stress Laboratory, Facultad de Ciencias, Universidad Autónoma de San Luis Potosí, Mexico http://orcid.org/0000-0002-0365-7783
  • F.J. González Terahertz Science and Technology Center (C2T2) and Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, Sierra Leona 550 Lomas 2a secc. San Luis Potosí, SLP, 78210 Mexico. http://orcid.org/0000-0002-1346-9073

DOI:

https://doi.org/10.31349/RevMexFis.65.651

Keywords:

Optical instruments and equipment, Neuroscience, Image forming and processing, Data acquisition, hardware and software.

Abstract

This paper describes the proof-of-concept evaluation of a low-cost imaging system for obtaining functional connectivity maps of in vivo murine models. This non-contact system is based on the Raspberry Pi 3 and its V2 camera and offers a method for obtaining resting-state images of brain activity without the use of extrinsic contrast agents. The system was fully characterized in terms of dark signal, linearity, sensor noise resolution and spatial frequency response. One mouse was observed in vivo and functional connectivity maps were obtained by combining resting-state analysis and optical intrinsic signals imaging. Intra-mouse variations in functional connectivity remain consistent across multiple imaging sessions. In principle, inexpensive optical imaging of intrinsic signals allows the study of the mechanisms underlying human brain disorders in well-controlled murine models.

Author Biographies

E. Guevara, CONACYT-Universidad Autónoma de San Luis Potosí Terahertz Science and Technology Center (C2T2) and Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, Sierra Leona 550 Lomas 2a secc. San Luis Potosí, SLP, 78210 Mexico.

Edgar Guevara is currently a CONACYTresearch fellow at UASLP-CIACYT. His current research interests are in non-invasive medical diagnosis, using optical imaging, functional connectivity, spectroscopy and biomedical signal processing. His past work includes research in epilepsy, cardiovascular disease, spinal cord injury and white matter injury in newborns. He has been awarded two CONACYT scholarships to pursue his graduate studies and a repatriation grant. He has been the technical specialist of a telemedicine project (proinnova 2015-2016) and bilateral cooperation program Mexico-Quebec (2016-2018).He was a former Associate Professor at Universidad de las Américas Puebla's Computing, Electronics and Mechatronics Department. His industrial experience includes work in the tire industry as maintenance supervisor and projects engineer. He received his PhD degree in Biomedical Engineering at École Polytechnique de Montréal in 2014, and his thesis earned a special mention from the jury. He holds a MSc degree from Universidad Autónoma de San Luis Potosí. He received a BS in Electronic Engineering from Instituto Tecnológico de San Luis Potosí (where he received recognition as the top student in 2003).

F.J. González, Terahertz Science and Technology Center (C2T2) and Science and Technology National Lab (LANCyTT), Universidad Autónoma de San Luis Potosí, Sierra Leona 550 Lomas 2a secc. San Luis Potosí, SLP, 78210 Mexico.

Professor at the Autonomous University of San Luis Potosi, graduated from the University of Central Florida working on Antenna-coupled detectors at CREOL (an optics institute). Current research deals with Biophotonics (Optical Methods for Noninvasive Clinical Diagnosis) and Nanophotonics (Interaction of Light with nanostructures).

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Published

2019-10-31

How to Cite

Guevara, E., M. Miranda-Morales, K. Hernández-Vidales, M. Atzori, and F.J. González. 2019. “Low-Cost Embedded System for Optical Imaging of Intrinsic Signals”. Revista Mexicana De Física 65 (6 Nov-Dec):651-57. https://doi.org/10.31349/RevMexFis.65.651.