Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water

Authors

  • G. Lopez -Laurrabaquio Instituto Nacional de Investigaciones Nucleares
  • H. S. Cruz-Galindo Instituto Nacional de Investigaciones Nucleares
  • M. Moranchel y Rodriguez
  • J. M. Montejano Carrizales Instituto de Física, UASLP
  • J. N. Domínguez Kondo Facultad de Ciencias Fisico matematicas, Benemerita Universidad Autonoma de Puebla.
  • M. P. Cruces Martinez Dpto. de Biologia, Instituto Nacional de Investigaciones Nucleares,

DOI:

https://doi.org/10.31349/RevMexFis.66.797

Keywords:

Monte Carlo, reactive species, Auger

Abstract

Through computer simulations of Monte Carlo (TOPAS-nBio code), the generation of reactive oxygen species will be analyzed when applying external radiation with electrons which energy is 3 and 5 keV to physical system: composite system and intracellular water. This study of the generation of reactive species was focused exclusively on the interaction between secondary radiation from the composite system and intracellular water.This secondary radiation originates from the platinum atom and oxygens (from the composite system) the influence being greater relative to platinum; which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account.

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Published

2020-11-05

How to Cite

[1]
G. Lopez -Laurrabaquio, H. S. Cruz-Galindo, M. Moranchel y Rodriguez, J. M. Montejano Carrizales, J. N. Domínguez Kondo, and M. P. Cruces Martinez, “Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water”, Rev. Mex. Fís., vol. 66, no. 6 Nov-Dec, pp. 797–802, Nov. 2020.